Their reasons for colonising were different throughout the Americas. England sent settlers to found colonies, but these new colonies in turn provided through indentured servitude a means for the displaced populations in England or those suffering from the continuous wars of religion to turn over a new leaf. Spain, on the other hand, had been fortunate enough to find those lands rich in natural resources and so their colonies centred around large urban centres like Mexico and Bogota with the purpose of administering the extraction of gold and other resources for shipping back to Spain. This is a very broad sweeping generalisation but I think it's fairly accurate. As for what went wrong in the colonies in the 19th century, see the American Revolutionary War and then Simon Bolivar and Latin American independence. Its other colonies of the Philippines and Guam were lost at the end of the 19th century in the Spanish-American War. There are many factors for why Spain lost control of its colonies and it would be inappropriate to only say that they followed what the American colonies did.As for how they treated the natives, they were labelled as "Black Spain" perhaps for a valid reason, but to say that England's colonies treated them better would not be true. Many native tribes likely got along very well with English settlers, like in early Pennsylvania, but they would always be pushed westwards eventually, and very often were the victims of massacre by the settlers.Also you can argue that England did not fare as well as Spain since they lost control of the Americas and India, which had a large population and fed directly into the British mercantilism system, not to mention vast territories, meaning that their losses were proportionally larger than Spain's. Spain lost essentially all of South America, but they had already shipped most of its gold to the mother country, and although they lost almost an entire continent they had not populated it and had not turned to agricultural cash crops like in British America to make it as valuable.

And those who fled the Inquisition for the New World did so in vain because it followed them to the Spanish and Portuguese colonies.

A 400 year “fad” ended by Napoleon's force of arms. It stifled the growth of science and commerce. Thanks to the Inquisition, home industries declined. All its wealth from the New World went into fighting wars vs. France and to save the Austrian habsburgs in the 17th century and paying high prices for imports because no home industries existed due to the expulsion of the Jews in 1492 and the Moriscos in 1609, plus the never-ending hounding of conversos and new-Christians. 15,000 new-Christian families fled Spain from 1643-1665 during the reign of Diego Arce Reynoso as Inquisitor General acording to his biographer.